Kelly's studies have shown that a systematic search for monoclonal proteins in plasma and urine among patients with neuropathy of unknown cause increases diagnostic yield. This book comprehensively examines chemotherapy-induced peripheral neuropathy CIPN , a common dose-limiting condition that negatively affects both the quality of life of cancer patients and disease outcomes.
Textbook of Peripheral Neuropathy. New York: demosMedical, , p. Assessing decreased sensation and increased sensory phenomena in diabetic polyneuropathies.
Lloyd Shield contributed a great deal to the final chapter on focal lesions of peripheral nerves. We frequently referred to the various editions of the major textbook , Peripheral Neuropathy by Dyck , Thomas and colleagues. Donofrio PD. Neuropathies associated with HIV infection and antiretroviral therapy. In: Textbook of Peripheral Neuropathy. New York: Demos Medical Publishing; — In general, abnormalities found with neuroPolyneuropathy may be defined as a diffuse, generally symmetrical, logical examination are mild.
The onset and duraAlthough most chronic axonal The book is organized into seven sections, starting with the general approach to the patient with neuromuscular disorders and then focusing on specific neuromuscular conditions affecting the peripheral nervous system from its origins at the This book is a comprehensive guide to the diagnosis and management of both common and rare neurological disorders, for practising neurologists and trainees.
Nerve conduction studies are extremely useful in detecting focal nerve injuries such as median neuropathy at the wrist in However , the topic of compression neuropathy does find a place Skip to content. Donofrio, MD Publisher: Demos Medical Publishing ISBN: Category: Medical Page: View: Textbook of Peripheral Neuropathy is a practical but authoritative reference for clinicians in anymedical specialty who are evaluating and treating patients with signs and symptoms of a peripheralneuropathy.
Coverage encompasses both inherited and acquired diseases, including neuropathies arisingfrom physical injury, diabetes, alcoholism, toxins, autoimmune responses, nutritional deficiencies, vascularand metabolic disorders, medication-induced neuropathies, and idiopathic conditions.
The textbookprovides an evidence-based approach to testing, differential diagnosis, and treatment, and should serveas a trusted resource for healthcare professionals confronting the many manifestations of peripheralneuropathy in clinical practice. The chapters are written by internationally renowned expert contributors with deep clinical experienceand contain numerous tables, figures, and algorithms providing clear diagnostic and managementguidelines. Boxed Clinical Pearls and Key Points allow for quick access to pertinent information, making evaluation and review easy and rewarding.
The book covers a broad range of neuropathies including mononeuropathy, mononeuritis multiplex, and polyneuropathy which accounts for the greatest number of cases and provides an evidence-based approach to testing, diagnosis, and treatment. They also include concise discussions of the causes of diabetic neuropathy and highlight the relatively unknown features of neuropathy that can significantly impact a patient's life. Comprehensive, up-to-date bibliographies at the end of each chapter provide an opportunity for the interested physician to gain a more detailed picture of a particular topic.
This book offers family physicians, internists, endocrinologists, podiatrists, cardiologists, neurologists, and gastroenterologists an authoritative practical guide and a vital day-to-day reference source for the management of their neuropathic diabetic patients. As a central integrating mechanism, overproduction of reactive oxygen species in peripheral nerves leads to oxidative stress, mitochondrial dysfunction, neuronal damage and finally apoptosis.
Oxidative stress results in an increase in substrate for AGEs and in precursors of glycoxidation and lipoxidation products, and accelerates the free radical formation that may be accompanied by or caused by a deficiency of antioxidant and detoxification pathways. Therefore, antioxidant treatment may improve neuronal repair in patients with diabetic neuropathy.
However, the true mechanisms by which increased oxidative stress affects downstream signaling mechanisms, and how this results in the development of diabetic neuropathy have not yet been thoroughly studied. Neither is it known whether antioxidant supplementation could help the damaged neurons to regenerate, and thus enable patients with diabetic neuropathy to overcome this devastating, life-threatening situation.
Vincent Publisher : Elsevier Inc. Glycemic control can decrease the incidence of neuropathy but is not adequate alone to prevent or treat the disease. This chapter introduces diabetic neuropathy with a morphological description of the disease then describes our current understanding of metabolic and molecular mechanisms that contribute to neurovascular dysfunctions. Key mechanisms include glucose and lipid imbalances and insulin resistance that are interconnected via oxidative stress, inflammation, and altered gene expression.
These complex interactions should be considered for the development of new treatment strategies against the onset or progression of neuropathy.
Advances in understanding the combined metabolic stressors and the novel study of epigenetics suggest new therapeutic targets to combat this morbid and intractable disease affecting millions of patients with type 1 or type 2 diabetes. Score: 5. Textbook of Diabetic Neuropathy Author : F. It also emphasizes the need to regain the grip on the basic sciences of clinical medicine to deal with it better - Anatomy, Physiology, Biochemistry and Pathology and gives the necessary details.
The volume aims at explaining what the clinicians need most to help patients and may not possess. When the diagnosis of neuropathy the symptoms depend on the peripheral nerves which are affected. The most characteristic motor symptoms of neuropathy are muscle weakness of h ands and feet, difficulty in flexion and extension of joints, gait disorders neuropathy of the sciatic nerve , involuntary contractions twitching of muscles. The symptoms of neuropathy associated with damage to sensitive nerves have the character of pain neuralgia in the affected area and along the nerve, numbness, dry skin or hyperhidrosis, hypersensitivity to external irritants hyperesthesia , sense of tingling, poor coordination of movements.
Autonomic symptoms of neuropathy may include a violation of sweating, blanching, redness or blueness of the skin and several other characteristics. There are specific symptoms of different types of neuropathy. So, neuropathy of the facial nerve is manifested by the immobility of the face usually on one side , skew asymmetry of the face, inability to close one eye.
Neuropathy of the sciatic nerve is manifested by such symptoms as numbness on the outside of the leg, pain in the thighs and calves, sagging of the foot during walking, inability to step on your toes and heels normally. The root cause of degenerative changes in the nervous tissues and the diagnosis of neuropathy may be a pinched nerve by muscles, ligaments, and bone tissues , tumor, trauma, metabolic disorders including vitamin deficiency , cardiovascular and other diseases.
In particular, polyneuropathy in some cases occurs as a complication of diabetes. Other diseases, in the background of which neuropathy occurs, are hypothyroidism, rheumatoid arthritis, polyarthritis, atherosclerosis.
The factors contributing to neuropathy are chronic alcoholism, kidney disease, malnutrition deficiency of vitamins and minerals , nature of professional activities, taking of certain medication. Violation of innervation of the muscles entails their gradual atrophy and violation of innervation of the internal organs entails the dysfunction of these organs. Violation of the nerves which are engaged in the innervation of the internal organs autonomic neuropathy leads to tachycardia, diarrhea, impaired urination, constipation, biliary dyskinesia, and other violations.
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